Trends Biochem Sci.
39:373-80.
Smith HC (2013)
Curing Academic/Industrial Ills.
Point of View, Genetic and Engineering
News 33:6-8.
Smith HC, Bennett RP, Kizilyer A,
McDougall WM, Prohaska KM (2012) ‘The Interaction of
APOBEC Family Members with RNA as a
Regulator of Cytidine Deaminase
Activity on DNA’, in Seminars
in Cell and Developmental Biology
(Maas, S., ed) Elsivier Press, 23:
258-268.
McDougall WM, Smith HC. (2011) Direct
Evidence that RNA Inhibits
APOBEC3G ssDNA Cytidine Deaminase
Activity Biochem Biophys Res
Commun. 412:612-7.
McDougall WM, Okany C, Smith HC
(2011) Deaminase
Activity on Single-stranded DNA
(ssDNA) Occurs in Vitro when
APOBEC3G Cytidine Deaminase
Forms Homotetramers and
Higher-order Complexes
J Biol Chem, 286: 30655–61
Smith HC
(2011)
APOBEC3G:
a double agent in defense. Trends Biochem
Sci. 2011 May;36(5):239-44.
Epub 2011 Jan 14, PMID:
21239176
Galloway CA,
Smith HC (2010)
The
expression of apoB mRNA
editing factors is not the
sole determinant for the
induction of editing in
differentiating Caco-2
cells. Biochem Biophys
Res Commun,391:659-63
Galloway CA,
Kumar A, Krucinska J, Smith HC
(2010)
APOBEC-1
complementation factor (ACF)
forms RNA-dependent
multimers. Biochem Biophys
Res Commun,398:38-43
Galloway CA,
Ashton J, Sparks JD, Mooney RA,
Smith HC (2010)
Metabolic
regulation of APOBEC-1
complementation factor
trafficking in mouse models
of obesity and its positive
correlation with the
expression of ApoB protein
in hepatocytes. Biochim Biophys
Acta,1802:976-85
Salter JD,
Krucinska J, Raina J, Smith HC,
Wedekind JE (2009) A
hydrodynamic analysis of
APOBEC3G reveals a
monomer-dimer-tetramer
self-association that has
implications for anti-HIV
function. Biochemistry,48:10685-7
Smith HC (2009)
The APOBEC1 Paradigm for
Mammalian Cytidine Deaminases
that Edit DNA and RNA, in DNA
and RNA Modifications Enzymes.
(Grosjean, H. ed), Landes
BioSciences, Invited Chapter 15
pp. 181-202.
Bennett RP,
Salter JD, Liu X, Wedekind JE,
Smith HC (2008)
APOBEC3G
Subunits Self-associate via
the C-terminal Deaminase
Domain. J Biol Chem,
283:33329-36
Bennett RP,
Presnyak V, Wedekind JE, Smith
HC (2008)
Nuclear
Exclusion of the HIV-1 host
defense factor APOBEC3G
requires a novel cytoplasmic
retention signal and is not
dependent on RNA binding. J Biol Chem,
283:7320-7
Smith HC
(2008)
RNA
and DNA Editing: Molecular
Mechanisms and Their
Integration into Biological
Systems. (H.C. Smith,
ed) 16 chapters, Wiley Press,
NY.
Lehmann DM,
Galloway CA, Macelrevey C,
Sowden MP, Wedekind JE, Smith HC
(2007)
Functional
characterization of APOBEC-1
complementation factor
phosphorylation sites. Biochim Biophys
Acta, 1773:408-18
Smith HC
(2007)
Measuring
editing activity and
identifying
cytidine-to-uridine mRNA
editing factors in cells and
biochemical isolates. In Methods in
Enzymology, RNA Editing &
Modification (Gott, J., eds)
Academic Press, NY, 424:389-416
Jin X, Wu H,
Smith HC (2007)
APOBEC3G
levels predict rates of
progression to AIDS. Retrovirology,
4:20-7
Miller HJ,
Presnyak V, Smith HC (2007)
The
dimerization domain of HIV-1
viral infectivity factor Vif
is required to block virion
incorporation of APOBEC3G. Retrovirology,
4:81-91
Bennett RP,
Diner E, Sowden MP, Lees JA,
Wedekind JE, Smith HC (2006)
APOBEC-1
and AID are
nucleo-cytoplasmic
trafficking proteins but
APOBEC3G cannot traffic. Biochem Biophys
Res Commun, 350:214-9
Ichikawa HT,
Sowden MP, Torelli AT, Bachl J,
Huang P, Dance GS, Marr SH,
Robert J, Wedekind JE, Smith HC,
Bottaro A (2006)
Structural
phylogenetic analysis of
activation-induced deaminase
function. J Immunol,
177:355-61
Wedekind JE,
Gillilan R, Janda A, Krucinska
J, Salter JD, Bennett RP, Raina
J, Smith HC (2006) Nanostructures
of APOBEC3G support a
hierarchical assembly model
of high molecular mass
ribonucleoprotein particles
from dimeric subunits. J Biol Chem,
281:38122-6
Smith HC
(2006)
Editing
Informational Content of
Expressed DNA Sequences and
Their Transcripts. The Implicit
Genome (Caporale, L.H. ed.)
Oxford University Press, NY,
Chapter 14, 248-265
Lehmann DM,
Galloway CA, Sowden MP, Smith HC
(2006)
Metabolic
regulation of apoB mRNA
editing is associated with
phosphorylation of APOBEC-1
complementation factor. Nucleic Acids
Res, 34:3299-308
Smith HC,
Wedekind JE, Xie K, Sowden MP
(2005)
Mammalian
C to U Editing. Topics in
Current Genetics: "Fine-Tuning
of RNA Functions by
Modification and Editing" H.
Grosjean (Ed.)
Springer-Verlag, Berlin,
1610-2096
Jin X, Brooks
A, Chen H, Bennett R, Reichman
R, Smith H (2005) APOBEC3G
(hA3G) mRNA Levels Associate
Inversely with Human
Immunodeficiency Virus
Viremia. J. Virology,
79:11513-6
Xie K, Sowden
MP, Dance GS, Torelli AT, Smith
HC, Wedekind JE (2004) The
structure of a yeast
RNA-editing deaminase
provides insight into the
fold and function of
activation-induced deaminase
and APOBEC-1. Proc Natl Acad
Sci U S A, 101:8114-9
Smith HC,
Bottaro A, Sowden MP, Wedekind
JE (2004)
Activation
induced deaminase: the
importance of being
specific. Trends Genet,
20:224-7
Sowden MP,
Lehmann DM, Lin X, Smith CO,
Smith HC (2004)
Identification
of novel alternative splice
variants of APOBEC-1
complementation factor with
different capacities to
support apolipoprotein B
mRNA editing. J Biol Chem,
279:197-206
Galloway CA,
Sowden MP, Smith HC (2003)
Increasing
the yield of soluble
recombinant protein
expressed in E. coli by
induction during late log
phase. Biotechniques,
34:524-6
Wedekind JE,
Dance GS, Sowden MP, Smith HC
(2003)
Messenger
RNA editing in mammals: new
members of the APOBEC family
seeking roles in the family
business. Trends Genet,
19:207-16
Sowden MP,
Ballatori N, Jensen KL, Reed LH,
Smith HC (2002)
The
editosome for cytidine to
uridine mRNA editing has a
native complexity of 27S:
identification of
intracellular domains
containing active and
inactive editing factors. J Cell Sci,
115:1027-39
Yang Y,
Ballatori N, Smith HC (2002)
Apolipoprotein
B mRNA editing and the
reduction in synthesis and
secretion of the atherogenic
risk factor, apolipoprotein
B100 can be effectively
targeted through
TAT-mediated protein
transduction. Mol Pharmacol,
61:269-76
Smith HC
(2002)
A
course director's
perspectives on
problem-based learning
curricula in biochemistry. Acad Med, 77:1189-98
Dance GS,
Sowden MP, Cartegni L, Cooper E,
Krainer AR, Smith HC (2002)
Two
proteins essential for
apolipoprotein B mRNA
editing are expressed from a
single gene through
alternative splicing. J Biol Chem,
277:12703-9
Sowden MP,
Smith HC (2001)
Commitment
of apolipoprotein B RNA to
the splicing pathway
regulates
cytidine-to-uridine
editing-site utilization. Biochem J,
359:697-705
Yang Y,
Sowden MP, Smith HC (2001)
Intracellular
trafficking determinants in
APOBEC-1, the catalytic
subunit for cytidine to
uridine editing of
apolipoprotein B mRNA. Exp Cell Res,
267:153-64
Giangreco A,
Sowden MP, Mikityansky I, Smith
HC (2001)
Ethanol
stimulates apolipoprotein B
mRNA editing in the absence
of de novo RNA or protein
synthesis. Biochem Biophys
Res Commun, 289:1162-7
Dance GS,
Beemiller P, Yang Y, Mater DV,
Mian IS, Smith HC (2001)
Identification
of the yeast cytidine
deaminase CDD1 as an orphan
C-->U RNA editase. Nucleic Acids
Res, 29:1772-80
Yang Y,
Sowden MP, Smith HC (2000)
Induction
of cytidine to uridine
editing on cytoplasmic
apolipoprotein B mRNA by
overexpressing APOBEC-1. J Biol Chem,
275:22663-9
Dance GS,
Sowden MP, Yang Y, Smith HC
(2000)
APOBEC-1
dependent cytidine to
uridine editing of
apolipoprotein B RNA in
yeast. Nucleic Acids
Res, 28:424-9
Steinburg MF,
Schock D, Backus JW, Smith HC
(1999)
Tissue-specific
differences in the role of
RNA 3' of the apolipoprotein
B mRNA mooring sequence in
editosome assembly. Biochem Biophys
Res Commun, 263:81-6
Siddiqui JF,
Van Mater D, Sowden MP, Smith HC
(1999)
Disproportionate
relationship between
APOBEC-1 expression and
apolipoprotein B mRNA
editing activity. Exp Cell Res,
252:154-64
Smith HC, Hundert EM (1999) Integrating
molecular medicine into the
medical school curriculum.
Molecular Medicine Today
5:102-103, Invited commentary.
Sowden MP,
Collins HL, Smith HC, Garrow
TA, Sparks JD, Sparks CE
(1999)
Apolipoprotein
B mRNA and lipoprotein
secretion are increased in
McArdle RH-7777 cells by
expression of
betaine-homocysteine
S-methyltransferase. Biochem J,
341 ( Pt 3):639-45
Van Mater
D, Sowden MP, Cianci J, Sparks
JD, Sparks CE, Ballatori N,
Smith HC (1998) Ethanol
increases apolipoprotein B
mRNA editing in rat
primary hepatocytes and
McArdle cells. Biochem
Biophys Res Commun, 252:334-9
Stewart J,
Kozlowski P, Sowden M, Messing
E, Smith HC (1998) A
quantitative assay for
assessing allelic
proportions by iterative
gap ligation. Nucleic Acids
Res, 26:961-6
Sowden MP,
Eagleton MJ, Smith HC (1998)
Apolipoprotein
B RNA sequence 3' of the
mooring sequence and
cellular sources of
auxiliary factors
determine the location and
extent of promiscuous
editing. Nucleic Acids
Res, 26:1644-52
Yang Y,
Kovalski K, Smith HC (1997)
Partial
characterization of the
auxiliary factors involved
in apolipoprotein B mRNA
editing through APOBEC-1
affinity chromatography. J Biol Chem,
272:27700-6
Smith HC
Gott JM Hanson MR (1997)
A
guide to RNA editing.. RNA, 3:1105-23
Yang Y,
Smith HC (1997) Multiple
protein domains determine
the cell type-specific
nuclear distribution of
the catalytic subunit
required for
apolipoprotein B mRNA
editing. Proc Natl
Acad Sci U S A, 94:13075-80
Sparks JD,
Collins HL, Sabio I, Sowden
MP, Smith HC, Cianci J, Sparks
CE (1997)
Effects
of fatty acids on
apolipoprotein B secretion
by McArdle RH-7777 rat
hepatoma cells. Biochim
Biophys Acta, 1347:51-61
Phung TL,
Sowden MP, Sparks JD, Sparks
CE, Smith HC (1996) Regulation
of hepatic apolipoprotein
B RNA editing in the
genetically obese Zucker
rat. Metabolism,
45:1056-8
Smith HC
Sowden MP (1996) Base-modification
mRNA editing through
deamination--the good, the
bad and the unregulated..
Trends
Genet., 12:418-24
Sowden M,
Hamm JK, Spinelli S, Smith HC
(1996)
Determinants
involved in regulating the
proportion of edited
apolipoprotein B RNAs. Rna, 2:274-88
Yang Y,
Smith HC (1996) In
vitro reconstitution of
apolipoprotein B RNA
editing activity from
recombinant APOBEC-1 and
McArdle cell extracts. Biochem
Biophys Res Commun, 218:797-801
Sowden M,
Hamm JK, Smith HC (1996)
Overexpression
of APOBEC-1 results in
mooring sequence-dependent
promiscuous RNA editing. J Biol Chem,
271:3011-7
Schock D,
Kuo SR, Steinburg MF,
Bolognino M, Sparks JD, Sparks
CE, Smith HC (1996) An
auxiliary factor
containing a 240-kDa
protein complex is
involved in apolipoprotein
B RNA editing. Proc Natl
Acad Sci U S A, 93:1097-102
Skuse GR,
Cappione AJ, Sowden M, Metheny
LJ, Smith HC (1996) The
neurofibromatosis type I
messenger RNA undergoes
base-modification RNA
editing. Nucleic Acids
Res, 24:478-85
Folpe A,
Lapham LW, Smith HC (1995)
Herpes
simplex myelitis as a
cause of the acute
necrotizing myelitis
syndrome. , 44:1955-1957
Davidson
NO, Innerarity TL, Scott J,
Smith HC, Driscoll DM, Teng
B, Chan L (1995) Proposed
nomenclature for the
catalytic subunit of the
mammalian apolipoprotein
B mRNA editing enzyme:
APOBEC-1. RNA,
1:3
Backus
JW, Schock D, Smith HC
(1994)
Only
cytidines 5' of the
apolipoprotein B mRNA
mooring sequence are
edited. Biochim
Biophys Acta, 1219:1-14
Backus
JW, Smith HC (1994)
Specific
3' sequences flanking
a minimal
apolipoprotein B
(apoB) mRNA editing
'cassette' are
critical for efficient
editing in vitro. Biochim
Biophys Acta, 1217:65-73
Smith HC, Howell RL &
Ludlow JW (1994)
"Alterations in cell cycle
control factors and the
induction of
oxygen-regulated stress
proteins by hypoxic
stress". Cell Biology of
Trauma. Lemasters, J.J.
and Oliver, C.,. : CRC
Press, Inc, 213-225
Ludlow
JW, Howell RL, Smith HC
(1993)
Hypoxic
stress induces
reversible
hypophosphorylation of
pRB and reduction in
cyclin A abundance
independent of cell
cycle progression. Oncogene,
8:331-9
Barnes
C, Smith HC (1993)
Apolipoprotein
B mRNA editing in
vitro is a
zinc-dependent
process. Biochem
Biophys Res Commun,
197:1410-4
Smith
HC (1993)
Apolipoprotein
B mRNA editing: the
sequence to the event.
Semin
Cell Biol, 4:267-78
Harris
SG, Sabio I, Mayer E,
Steinberg MF, Backus JW,
Sparks JD, Sparks CE,
Smith HC (1993) Extract-specific
heterogeneity in
high-order complexes
containing
apolipoprotein B mRNA
editing activity and
RNA-binding proteins.
J
Biol Chem, 268:7382-92
Backus
JW, Smith HC (1992)
Three
distinct RNA sequence
elements are required
for efficient
apolipoprotein B
(apoB) RNA editing in
vitro. Nucleic
Acids Res, 20:6007-14
Sparks
JD, Zolfaghari R, Sparks
CE, Smith HC, Fisher EA
(1992)
Impaired
hepatic apolipoprotein
B and E translation in
streptozotocin
diabetic rats. J Clin
Invest, 89:1418-30
Harris
SG, Smith HC (1992)
In
vitro apolipoprotein B
mRNA editing activity
can be modulated by
fasting and refeeding
rats with a high
carbohydrate diet. Biochem
Biophys Res Commun,
183:899-903
Smith HC (1992)
"Organization of nuclear
mRNA splicing domains" In:
Current Topics in Cell
Regulation Academic
Press, New York, NY.
Vol. 34 p.145-166
Butler
AJ, Eagleton MJ, Wang D,
Howell RL, Strauch AR,
Khasgiwala V, Smith HC
(1991)
Induction
of the proliferative
phenotype in
differentiated
myogenic cells by
hypoxia. J Biol
Chem, 266:18250-8
Roll
DE, Murphy BJ, Laderoute
KR, Sutherland RM, Smith
HC (1991)
Oxygen
regulated 80 kDa
protein and glucose
regulated 78kDa
protein are identical.
Mol
Cell Biochem, 103:141-8
Smith
HC, Kuo SR, Backus JW,
Harris SG, Sparks CE,
Sparks JD (1991) In
vitro apolipoprotein B
mRNA editing:
identification of a
27S editing complex. Proc Natl
Acad Sci U S A, 88:1489-93
Backus
JW, Smith HC (1991)
Apolipoprotein
B mRNA sequences 3' of
the editing site are
necessary and
sufficient for editing
and editosome
assembly. Nucleic
Acids Res, 19:6781-6
Boix J,
Habets WJ, van Venrooij
WJ, Smith HC (1990)
Analysis
of U1snRNP-specific A
protein cross-linked
complexes. FEBS Lett,
272:213-6
Backus
JW, Eagleton MJ, Harris
SG, Sparks CE, Sparks JD,
Smith HC (1990) Quantitation
of endogenous liver
apolipoprotein B mRNA
editing. Biochem
Biophys Res Commun,
170:513-8
Liew
CC, Smith HC (1989)
Immunological
evidence for the role
of phosphoprotein
p68/pI = 7.3 in
premessenger RNA
splicing. FEBS Lett,
248:101-4
Smith HC (1989) "Ribonucleoprotein
organization: from
cell nucleus to RNP",
In: Structural
Aspects of Metabolic
Regulation UCLA
Symp. Molec. Cell.
Biol. Srere, P.,
Jones, M.E. and Mathews,
C. eds., A.R. Liss, Inc.,
134:43-56.
Smith
HC, Harris SG, Zillmann M,
Berget SM (1989) Evidence
that a nuclear matrix
protein participates
in premessenger RNA
splicing. Exp Cell
Res, 182:521-33
Harris
SG, Martin TE, Smith HC
(1988)
Reversible
chemical cross-linking
and ribonuclease
digestion analysis of
the organization of
proteins in
ribonucleoprotein
particles. Mol Cell
Biochem, 84:17-28
Harris
SG, Smith HC (1988)
SnRNP
core protein
enrichment in the
nuclear matrix. Biochem
Biophys Res Commun,
152:1383-7
Harris
SG, Hoch SO, Smith HC
(1988)
Chemical
cross-linking of Sm
and RNP antigenic
proteins. Biochemistry,
27:4595-600
Smith
HC, Ochs RL, Lin D,
Chinault AC (1987)
Ultrastructural
and biochemical
comparisons of nuclear
matrices prepared by
high salt or LIS
extraction. Mol Cell
Biochem, 77:49-61
Smith
HC, Rothblum LI (1987)
Ribosomal
DNA sequences attached
to the nuclear matrix.
Biochem
Genet, 25:863-79
Smith
HC, Ochs RL, Fernandez EA,
Spector DL (1986) Macromolecular
domains containing
nuclear protein p107
and U-snRNP protein
p28: further evidence
for an in situ nuclear
matrix. Mol Cell
Biochem, 70:151-68
Spector
DL, Smith HC (1986)
Redistribution
of U-snRNPs during
mitosis. Exp Cell
Res, 163:87-94
Busch H, Ochs RL, Smith HC
& Spector DL (1985) Nuclear
antigenic structures.
Scan. J.
Rheum. 56:10-21.
Smith HC, Spector DL,
Woodcock CLF, Ochs RL,
Bhorjee J (1985)
Alterations
in chromatin
conformation are
accompanied by
reorganization of
nonchromatin
domains that
contain U-snRNP
proteins and
nuclear protein
p107. J.
Cell Biol., 101:560-567
Gupta
RC, Dighe NR,
Randerath K, Smith HC
(1985)
Distribution
of initial and
persistent
2-acetylaminofluorene-induced
DNA adducts within
DNA loops. Proc
Natl Acad Sci U S A,
82:6605-8
Tubo
RA, Smith HC, Berezney
R (1985) The
nuclear matrix
continues DNA
synthesis at in
vivo replicational
forks. Biochim
Biophys Acta, 825:326-34
Smith
HC, Berezney R,
Brewster JM, Rekosh D
(1985)
Properties
of adenoviral DNA
bound to the
nuclear matrix. Biochemistry,
24:1197-1202
Smith
HC, Puvion E,
Buchholtz LA, Berezney
R (1984) Spatial
distribution of
DNA loop
attachment and
replicational
sites in the
nuclear matrix. J
Cell Biol, 99:1794-802
Smith
HC, Berezney R (1983)
Dynamic
domains of DNA
polymerase alpha
in regenerating
rat liver. Biochemistry,
22:3042-6
Berezny R, Basler J,
Bucholtz LA, Smith HC
& Siegel A. (1982)
Nuclear organization
and DNA
replication.
The Nuclear Envelope
and Nuclear Matrix.
(Maul, G.G., ed.) A.R.
Liss Pub. Co., pp.
183-197
Smith
HC, Berezney R (1982)
Nuclear
matrix-bound
deoxyribonucleic
acid synthesis: an
in vitro system. Biochemistry,
21:6751-61
Smith
HC, Berezney R (1980)
DNA
polymerase alpha
is tightly bound
to the nuclear
matrix of actively
replicating liver.
Biochem
Biophys Res Commun,
97:1541-7